At HAI, Scientists Ask If Tangles Are to Blame for Patchy Plaque Clearance
Postmortem and imaging show that immunotherapies mop up plaques well in some brain regions, but struggle in others. Tangles might be the roadblock.

With Age, Synaptic Protein Turnover Stalls, Choking Microglia
In old mice, synaptic proteins lingered twice as long, aggregated in neurons, and crammed microglial lysosomes. Could sluggish disposal underlie synapse loss?

Without ApoE3 or ApoE4, Alzheimer’s Would be a Rare Disease
Using relatively rare ApoE2 homozygotes as the new standard, a large study paints ApoE3 as a risk allele alongside ApoE4.

Microglia Lookalikes Deliver Progranulin in Mouse Lentivirus Gene Therapy A new approach toward restoring progranulin in frontotemporal dementia reduced cellular pathology in mice lacking the protein.